Acidosis láctica, en relación con insuficiencia renal aguda y metformina, tratada con hemodiálisis con bicarbonatoA Case of lactic acidosis related to acute renal . Lactic acidosis is a medical condition characterized by the buildup of lactate ( especially L-lactate) in the body, which results in an excessively low pH in the. Review Article from The New England Journal of Medicine — Lactic Acidosis.

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Non-fatal hyperkalemia in lactic acidosis due to metformin overdose. Report of one case.

He was admitted with abdominal pain, nausea, vomiting, diarrhea and loss of consciousness. At admission, he was disoriented and agitated with signs of poor perfusion.

Biochemical profile revealed an extreme hyperkalemia of Arterial blood gases revealed severe lactic acidemia. He was admitted to the Intensive Care Unit ICU with the suspicion of lactic acidosis associated with metformin, receiving fluid management, intravenous hypertonic glucose plus insulin and sodium bicarbonate, mechanical acidosks, vasopressor therapy, a temporary pacemaker lead, in addition to continuous venovenous hemodiafiltration.

Two days later, the patient experienced a significant clinical improvement with normalization of the acid-base status, plasma lactate and potassium levels. On day 9, diuresis was recovered, creatinine and uremia returned to normal levels and the patient was discharged from the ICU.


Acidosis, lactic; Hyperkalemia; Metformin. La acidosis asociada al uso de metformina, es de baja incidencia pero elevada mortalidad United Kingdom Prospective Diabetes Study Ann Intern Med ; Effect lactiica intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes UKPDS Medical management of hyperglycemia in type 2 diabetes: Comparative effectiveness and safety of medications for type 2 diabetes: Phenformin and lactic acidosis: J Emerg Med ; Diabetes Care ; Biguanide related lactic acidosis: Arch Med Res ; Rev Med Chile ; Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: Arch Intern Med ; Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

ACIDOSIS LACTICA by Pamela Davila on Prezi

Cochrane Database Syst Rev ; 4: Can acute overdose of metformin lead to lactic acidosis? Am J Emerg Med ; Prolonged lactcia for severe metformin intoxication. Ren Fail ; Occult metformin toxicity in three patients with profound lactic acidosis. Lactic acidosis in patients with diabetes treated with metformin. N Engl J Med ; Lactic acidosis induced by metformin: Drug Saf ; Incidence of lactic acidosis lxctica metformin users.


Acute kidney failure and severe lactic acidosis caused by metformin successfully treated with hemodialysis.

Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis. Nephrol Dial Transplant ; Med Clin North Am ; Aronson PS, Giebisch G. Effects of pH on Potassium: Ackdosis Explanations for Old Observations.

J Am Soc Nephrol ; Changes in plasma potassium concentration during acute acid-base disturbances. Am J Med ; Beta-adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects. Am J Hypertens ; Lactkca syndromes associated with nonsteroidal antiinflammatory drugs.

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Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure. Am Heart J ; Montoliu J, Revert L. Lethal hyperkalemia associated with severe hyperglycemia in diabetic patients with renal failure. Am J Kidney Dis ; 5: Extreme Hyperkalemia, South Med J ; Recibido el 1 de septiembre deaceptado el 23 de diciembre de