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Ez esetben nem tudja oldalunkat megtekinteni.

The numbers have been mixed up, and they do not correspond to the original numbers! Although the cases are the same altogether, please try to do the classification by completely ignoring the first series. You can access the slides at: You can also download the materials slides, instructions and spreadsheet at: You should fill in the accompanying spreadsheet, excel file and you should send it back to me, i.

Wall painting at Kalocsa

Deadline for this is 15 March Those of you, who did the test earlier, please ignore your previous results, and read the series again. It would be nice, if you could record the time required for completing the 50 cases if you do this in multiple sessions, make the addition of the session lengthsso please do it.


Because of previous experience with similar studies, may I just quote to you a text by our group about the definition. This is at the end of this text — try to adhere to it as much as possible.

The aim of the study in this case is only to assess the diagnostic kinfse of microinvasion therefore the excel file is much shorter, with only one column to fill in. A tumour in which the dominant lesion is in-situ carcinoma usually extensive high nuclear grade DCIS, kalpcsa other types of DCIS or lobular intraepithelial neoplasia but in which there are one or more clearly separate foci of infiltration of non specialized interlobular or interductal fibrous or adipose tissue, none measuring more than 1 mm about 2 hpf in maximum diameter.

This definition has been officially reported in the TNM system as pT1mic since fifth edition It is very restrictive and tumours fulfilling the criteria are consequently rare. The cells deemed kalosa be invasive must be distributed in a fashion non-organoid pattern that does not represent tangential sectioning of a duct or a lobular structure with in-situ carcinoma.


Tangentially sectioned in-situ carcinoma foci that simulate microinvasion are distributed in the specialized periductal and intralobular stroma and usually occur as compact groups of tumour cells that have a smooth border surrounded by a circumferential layer of myoepithelial cells and stroma or a thickened basement membrane At sites of microinvasive foci, tumour cells are distributed singly or as small groups that have irregular shapes reminiscent of conventional invasive carcinoma with no particular orientation There is complete absence of surrounding basement membrane and myoepithelial cells: Detecting microinvasion can be difficult when there is a marked periductal fibrosis or inflammation because the true boundary of the specialized periductal or lobular stroma is not clear, but immunostaining for cytokeratin may be useful to confirm the presence of separate foci of neoplastic cells embedded in periductal fibrosis or inflammation.